Univ. Bordeaux


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Title: Ph.D.

Status 1: Researcher (CR1, CEA)

Address :
University of Bordeaux, PAC Carreire, 146 Rue Léo-Saignat, Case 71, CS 61292, 33076 Bordeaux, FRANCE
Phone : +33 5 47 30 44 02
Email :

Date of birth: November 8th, 1967

Degrees :

  • 2006: Habilitation Thesis, Caen University
  • 1997: PhD in Bioengineering, Paris 12 University
  • 1992: Prelim’s in Bioengineering, Paris 12 University
  • 1991: Master’s degree in physical science and applications, Paris 7 University

Career :
November 1992 – June 1997:
PhD thesis in the Neurofunctional Imaging Group (director Pr. Bernard Mazoyer) – Detection and localization of cerebral activated areas using positron emission tomography.
July 1997 - November 1998:
Post-doctoral fellow in the Neurofunctional Imaging Group. EU program – "European Computerized Human Brain Database, Per Roland coordinator. Karolinska Institute, Sweden".
Since December 1998:
Researcher in the Neurofunctional Imaging Group (director Pr. Bernard Mazoyer), UMR5296 CEA-CNRS-Bordeaux University.

Current Research topics:

My research theme focuses on the anatomical basis of brain organization in humans and in particular on the study of the neuroanatomy of hemispheric specialization and brain anatomy of aging. I address these questions by exploiting polymorphic databases, obtained in thousands of elderly and young subjects, including demographic, biological, genetic, psychometric and neuroanatomical datasets. The use of powerful and convenient method such as Voxel-Based Morphometry coupled with population studies is a powerful approach to quantify the impact of the determinants of brain organization (volume, asymmetries, relationships with genetic polymorphisms and cognitive). In a first step, the EVA and 3C databases (850 and 3500 subjects over 65 respectively), allowed me to better characterize the effects of age, sex and the ApoE gene polymorphism on the neuroanatomical bases of aging in the elderly. In a second step, this generic approach has been used to analyse two databases acquired in the young, (274 and 300 subjects from 18 to 50 years respectively) to study the relationship between manual skills and anatomical lateralization of motor networks, the differences in anatomical organization between right-handed and left-handed subjects, the impact of familial sinistrality on brain asymmetries and on the markers of hemispheric specialization for language.

Publications (since 2007):

At October 1st, 2012: Total of 50 scientific publications in English journals (Nature Genetic, Nature Neuroscience, Neurology, Cerebral Cortex, NeuroImage, Human Brain Mapping,...). Mean Impact factor = 6.12

  • 1. Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi S-H, Sigurdsson S, Verhaaren BFJ, DeStefano AL, Lambert J-C, Jack CR, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RFAG, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MMB, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth T, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S (2012) Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet 44:545-551. (PDF)
  • 2. Dumurgier J, Crivello F, Mazoyer B, Ahmed I, Tavernier B, Grabli D, François C, Tzourio-Mazoyer N, Tzourio C, Elbaz A (2012) MRI atrophy of the caudate nucleus and slower walking speed in the elderly. NeuroImage.(PDF)
  • 3. Godin O, Dufouil C, Maillard P, Delcroix N, Mazoyer B, Crivello F, Alpérovitch A, Tzourio C (2008) White matter lesions as a predictor of depression in the elderly: the 3C-Dijon study. Biol Psychiatry 63:663-669. (PDF)
  • 4. Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P (2012) Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology 79:642-650. (PDF)
  • 5. Doucet G, Naveau M, Petit L, Zago L, Crivello F, Jobard G, Delcroix N, Mellet E, Tzourio-Mazoyer N, Mazoyer B, Joliot M (2012) Patterns of hemodynamic low-frequency oscillations in the brain are modulated by the nature of free thought during rest. NeuroImage 59:3194-3200. (PDF)
  • 6. Naveau M, Doucet G, Delcroix N, Petit L, Zago L, Crivello F, Jobard G, Mellet E, Tzourio-Mazoyer N, Mazoyer B, Joliot M (2012) A Novel Group ICA Approach Based on Multi-scale Individual Component Clustering. Application to a Large Sample of fMRI Data. Neuroinformatics. 10(3):269-85 (PDF)
  • 7. Stewart R, Godin O, Crivello F, Maillard P, Mazoyer B, Tzourio C, Dufouil C (2011) Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. The British Journal of Psychiatry 198:199 -1205. (PDF)
  • 8. Tzourio-Mazoyer N, Petit L, Razafimandimby A, Crivello F, Zago L, Jobard G, Joliot M, Mellet E, Mazoyer B (2010) Left Hemisphere Lateralization for Language in Right-Handers Is Controlled in Part by Familial Sinistrality, Manual Preference Strength, and Head Size. Journal of Neuroscience 30:13314-13318. (PDF)
  • 9. Beaucousin V, Zago L, Hervé PY, Strelnikov K, Crivello F, Mazoyer B, Tzourio-Mazoyer N (2011) Sex-dependent modulation of activity in the neural networks engaged during emotional speech comprehension. Brain Res 1390:108-117. (PDF)
  • 10. Doucet G, Naveau M, Petit L, Delcroix N, Zago L, Crivello F, Jobard G, Tzourio-Mazoyer N, Mazoyer B, Mellet E, Joliot M (2011a) Brain activity at rest: A multi-scale hierarchical functional organization. J Neurophysiol. (PDF)
  • 11. Crivello F, Lemaître H, Dufouil C, Grassiot B, Delcroix N, Tzourio-Mazoyer N, Tzourio C, Mazoyer B (2010) Effects of ApoE-epsilon4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons. NeuroImage 53:1064-1069. (PDF)
  • 12. Tzourio-Mazoyer N, Simon G, Crivello F, Jobard G, Zago L, Perchey G, Hervé PY, Joliot M, Petit L, Mellet E, Mazoyer B (2010) Effect of familial sinistrality on planum temporale surface and brain tissue asymmetries. Cereb Cortex 20:1476-1485. (PDF)
  • 13. Delamillieure P, Doucet G, Mazoyer B, Turbelin MR, Delcroix N, Mellet E, Zago L, Crivello F, Petit L, Tzourio-Mazoyer N, Joliot M (2010) The resting state questionnaire: An introspective questionnaire for evaluation of inner experience during the conscious resting state. Brain Res Bull 81:565-573. (PDF)
  • 14. Godin O, Tzourio C, Rouaud O, Zhu Y, Maillard P, Pasquier F, Crivello F, Alpérovitch A, Mazoyer B, Dufouil C (2010) Joint effect of white matter lesions and hippocampal volumes on severity of cognitive decline: the 3C-Dijon MRI study. J Alzheimers Dis 20:453-463. (PDF)
  • 15. Stip E, Mancini-Marïe A, Letourneau G, Fahim C, Mensour B, Crivello F, Dollfus S (2009) Increased grey matter densities in schizophrenia patients with negative symptoms after treatment with quetiapine: a voxel-based morphometry study. International Clinical Psychopharmacology 24:34-41. (PDF)
  • 16. Soumaré A, Elbaz A, Zhu Y, Maillard P, Crivello F, Tavernier B, Dufouil C, Mazoyer B, Tzourio C (2009) White matter lesions volume and motor performances in the elderly. Ann Neurol 65:706-715. (PDF)
  • 17. Maillard P, Crivello F, Dufouil C, Tzourio-Mazoyer N, Tzourio C, Mazoyer B (2009) Longitudinal follow-up of individual white matter hyperintensities in a large cohort of elderly. Neuroradiology 51:209-220. (PDF)
  • 18. Stewart R, Dufouil C, Godin O, Ritchie K, Maillard P, Delcroix N, Crivello F, Mazoyer B, Tzourio C (2008) Neuroimaging correlates of subjective memory deficits in a community population. Neurology 70:1601-1607. (PDF)
  • 19. Maillard P, Delcroix N, Crivello F, Dufouil C, Gicquel S, Joliot M, Tzourio-Mazoyer N, Alpérovitch A, Tzourio C, Mazoyer B (2008) An automated procedure for the assessment of white matter hyperintensities on multispectral (T1, T2, PD) MRI and its between-centre reproducibility evaluation on two large community databases. Neuroradiology 50:31-42. (PDF)