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TZOURIO-MAZOYER Nathalie


orcid.org/0000-0002-6236-4390
Google Scholar and research gate profiles:
https://scholar.google.fr/citations?user=NBszKugAAAAJ&hl=fr
https://www.researchgate.net/profile/Nathalie_Tzourio-Mazoyer?ev=hdr_xprf

EDUCATION

1997: Habilitation thesis in neuroscience, University of Caen, France
1987-1989: Board certification in nuclear medicine, Paris 12 University, France
1986-1987: Master degree in Neurosciences, Paris 7 University, France
1973-1984: Medical degree, Cochin Port-Royal Hospital, Paris 5 University, France

POSITIONS

2011-2016: Research Director at Atomic Energy Commission, Life Sciences Direction Scientific program Coordinator of the Groupe d’Imagerie Neurofonctionnelle (GIN) -a joint research unit of CNRS, CEA & Bordeaux University (F)

2007-2010: Head GINLANG laboratory, coordinator of Functional Imaging Department (DGIN) of CINAPS, CNRS, CEA & Caen university, Caen (F)

2004-2007: Head LaSCaR team (Language Schizophrenia, Calculation and Representation), CEA, CNRS, Caen & Paris 5 universities, Caen (F)

2000-2004: Head « Language & reasoning » team, Functional Neuroimaging Group, CEA, CNRS & Caen University; coordinator of the functional imaging department in the GIN, Caen (F)

1996-2000: Head team “Functional and anatomical imaging of human cognition”, GIN (Functional Neuroimaging Group), CEA & Caen University, GIP Cyceron, Caen (F)

1992-1996: Staff scientist at Atomic Energy Commission, Researcher, Functional neuroimaging group, CEA & Paris 7 University, Orsay (F)

1988-1992: Resident and researcher, Functional Neuroimaging Group, Atomic Energy Commission, Orsay (F)

FELLOWSHIPS AND AWARDS

2012: Neuroimage Best paper award (for the article in Neuroimage, 59:3194-3200)
2003: Dagnan-Bouveret Prize, Académie des Sciences Morales et Politiques, France
1993: Seymour CRAY Prize for numerical simulation
1991: IBM Prize for intensive numerical calculus (nominee)

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

1995-2013: Supervision of 12 PhD students: L PETIT (Paris 6 University, 1995), E MELLET (Paris 6 University, 1996), L ZAGO (Lyon University, 2000), O ETARD (Paris 6 University, 2000), S BRICOGNE (Paris 11 University, 2001), G JOSSE (Caen, University, 2003), PY HERVE (Caen University, 2005), G JOBARD (Caen University, 2002), A RAZAFIMANDIMBY (Caen University, 2005), M VIGNEAU (Caen University), V BEAUCOUSIN (Caen University, 2006), D MARIE (Bordeaux University, 2013).

1995-2013: Supervision of 17 Master students and 4 Postdocs and been a member of jury for 6 PhD theses and 5 Habilitation theses.

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2013: Cognitive neuroscience of language (US)
2000: Society for Neurosciences (US)
1995: Organization for Human Brain Mapping (US)

RESEARCH ACHIEVEMENTS SUMMARY

Early career. In my early work I applied a new technique, positron emission tomography (PET), with 15O-labeled water, capable of providing fast, quantitative and repeatable three-dimensional (3D) maps of cerebral blood flow in people while performing cognitive activities. Hence I was the first in France and among the first in Europe, to contribute to the development of cognitive neuroimaging as a new field of research through pioneering publications (Brain Research 1992, Journal of Cognitive Neuroscience 1993; Journal of Neurophysiology 1993; Neuroimage 1995).

Contributions to cognitive neuroimaging methods. I have conceived and produced a numerical atlas (AAL) of brain regions of interest (ROIs) for automatic neuroanatomical labeling, now a standard in the neuroimaging field (Neuroimage 2002; 3,500+ citations). AAL has been incorporated in the widely distributed SPM software package and licensed to the Miranda Solutions software company in 2005. I have also developed a methodology for meta-analyzing the neuroimaging literature in order to produce 3D maps of reported activation peaks. This allowed a precise mapping of phonological, semantic and syntactic networks giving insight into the neural organization of language (Neuroimage 2006, 534 citations; Neuroimage 2011, 85 citations; highly cited papers, ISI Web of Knowledge). I also discovered that large-scale neural networks support brain activity at rest, demonstrating that a set of ROIs was more active during rest than during any of a battery of cognitive tasks (Brain research Bulletin 2001, 473 citations). Over recent years, I have extended these studies, uncovering with fMRI a hierarchical organization of the brain during rest and developing a questionnaire on the mental content during rest (Journal of Neurophysiology 2010; Neuroimage 2012 best paper awards, Brain Research Bulletin 2010).

Contributions to the functional neuroanatomy of language and its sources of variability. My primary interest has been the study of the neural bases of language and their variability, whether it was produced, read (Journal of Neurolinguistics 2011, Neuroimage 2007), heard (J Neurosci 2010, Brain research 2011, Neuroimage 2012, PloS one 2013), or signed (Brain and Language 2010, Brain Research Bulletin 2011). I applied this knowledge to understand language networks alterations in schizophrenic patients (Biological Psychiatry 2005, Schizophrenia Research 2007, 2008, 2010 & 2011, Schizophrenia Bulletin 2007 & 2009, Neuropsychologia 2011). I also provided the first evidence that manual preference (MP) has a larger impact on language production than language perception areas, while larger left PT surface area explains part of the variability of perceptive regions only (Brain research 2006) thereby explaining the existence of above mentioned dissociations. I further demonstrated that individuals having a left-hander in their close relatives (familial sinistrality, FS) had a reduction in the size of their left PT, regardless of their own MP (Cerebral Cortex 2009), and confirmed the importance of FS by showing loss of hemispheric language asymmetry in right-handers individuals with low manual lateralization and FS (J Neurosci 2010).

Revisiting hemispheric specialization with neuroimaging. Most recently I have focused my research on the phenomenon of hemispheric specialization (HS), and started the BIL&GIN project (Brain Imaging lateralization & GIN, Mazoyer 2015) with my colleagues of the GIN, coordinating the design and acquisition of a neuroimaging /psychometric/DNA database of 453 healthy participants, enriched to 50% of left-handers. Initial results include reference data such as the description of the resting-state networks obtained in 430 participants (Naveau 2012), and the occurrence of Heschl’s gyri duplications that, when leftward, are associated with lower leftward functional asymmetry during speech listening (Brain Structure and Function 2014a and 2014b). I also have established the absence of association between MP and language lateralization, except in a small group of left-handed subjects strongly lateralized to the right for language and to the left for their MP (PlosOne 2014), opening new perspectives on genetic studies. Considering brain hemispheric lateralization, I demonstrated a benefit to be lateralized for language, independently of the lateralization side, and of the type of cognitive skill (Neuropsychologia 2014). This initial research outcomes led me to revisit the topic of HS, highlighting the promising advances that brain imaging can bring to this question (TICS 2013), and reinforced my conviction that groundbreaking research for understanding HS was needed.

REPRESENTATIVE PUBLICATIONS

1. Tzourio-Mazoyer N, Josse G, Crivello F, Mazoyer B (2004) Interindividual variability in the hemispheric organization for speech. Neuroimage 21:422-435.N citations 68
2. Vigneau M, Jobard G, Mazoyer B, Tzourio-Mazoyer N (2005). Word and non-word reading: what role for the Visual Word Form Area? Neuroimage 27:694-705. N citations 83
3. Dollfus S, Razafimandimby A, Delamillieure P, Brazo P, Joliot M, Mazoyer B, Tzourio-Mazoyer N (2005). Atypical hemispheric specialization for language in right-handed schizophrenia patients. Biological Psychiatry 7:1020-8. N citations 54
4. Vigneau M, Beaucousin V, Herve PY, Duffau H, Crivello F, Houde O, Mazoyer B, Tzourio-Mazoyer N (2006). Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. Neuroimage 30:1414-1432. N citations 534 (highly cited paper, ISI Web of Science)
5. Herve PY, Crivello F, Perchey G, Mazoyer B, Tzourio-Mazoyer N (2006). Handedness and cerebral anatomical asymmetries in young adult males. Neuroimage. 29:1066-79. N citations 81
6. Beaucousin V, Lacheret A, Turbelin MR, Morel M, Mazoyer B, Tzourio-Mazoyer N (2007) FMRI Study of Emotional Speech Comprehension. Cerebral Cortex 84:359-364. N citations 57
7. Jobard G, Vigneau M, Mazoyer B, Tzourio-Mazoyer N (2007) Impact of modality and linguistic complexity during reading and listening tasks. Neuroimage 34:784-800. N citations 41
8. Zago L, Petit L, Turbelin MR, Andersson F, Vigneau M, Tzourio-Mazoyer N (2008) How verbal and spatial manipulation networks contribute to calculation: an fMRI study. Neuropsychologia 46:2403-2414. N citations 49
9. Vigneau M, Beaucousin V, Hervé PY Jobard G, Petit L, Crivello F, Mellet E, Zago L, Mazoyer B, Tzourio-Mazoyer N (2011) What is right hemisphere contribution to phonological, lexico-semantic and sentence processing? Insights from a meta-analysis. Neuroimage. 54:577-593. N citations 85 (highly cited paper, ISI Web of Science
10. Hervé PY, Zago L, Jobard G, Mazoyer B, Tzourio-Mazoyer N (2013) Revisiting human hemispheric specialization with neuroimaging. Trends in Cognitive Sciences 17:69-80. N 18 citations (highly cited paper, ISI Web of Science)

IMPACT (March 2015)

H-Factor = 47 (ISI Web of Science), = 47 (Google scholar)
Number of citations = 10,150 (ISI), = 15,593 (Google scholar)
Most cited article: Neuroimage 2002, 3,500 cites
Highly cited papers : 3 (Neuroimage 2006, Neuroimage 2011, TICS 2013)
Listed in the top 1% scientists in Neurosciences & Behavior, and in All fields