Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain.
N. Tzourio-Mazoyer, B. Landeau, D. Papathanassiou, F. Crivello, O. Étard, N. Delcroix, B. Mazoyer, and M. Joliot. NeuroImage 2002. 15 :273-289 (PDF)
An automated anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute (MNI) (D. L. Collins et al., 1998, Trans. Med. Imag. 17, 463–468, PubMed) was performed. Using this parcellation method, three procedures to perform the automated anatomical labeling of functional studies are proposed: (1) labeling of an extremum defined by a set of coordinates, (2) percentage of voxels belonging to each of the AVOI intersected by a sphere centered by a set of coordinates, and (3) percentage of voxels belonging to each of the AVOI intersected by an activated cluster. An interface with the Statistical Parametric Mapping package is provided as a freeware to researchers of the neuroimaging community.
The outline of the parcellation was overlaid on the MNI single-subject z 5 0 mm axial slice. (A) Local maxima labeling: the red cross indicates the location of the local maximum. (B) Extended local maxima labeling: percentage of overlap between a 10-mm sphere radius centered on the local maximum and the AVOI parcellation. (C) Cluster labeling: percentage of overlap between the activation cluster and the AVOI parcellation.
Illustration of the automated anatomical labeling SPM interface. (A) Maximum intensity projection and corresponding result table as provided by the SPM result section. (B) Output of the local maxima labeling. (C) Output of the extended local maxima labeling. (D) Output of the cluster labeling procedure.